ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
نویسندگان
چکیده
منابع مشابه
Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND).
BACKGROUND Riluzole 100 mg probably prolongs survival in patients with amyotrophic lateral sclerosis by about two months and the safety of the drug is not a major concern. The evidence from randomized controlled trials indicates that patients taking riluzole probably survive longer than patients taking placebo. The beneficial effects are very modest and the drug is expensive. Adverse effects fr...
متن کاملALS and other motor neuron diseases.
PURPOSE OF REVIEW This review describes the most common motor neuron disease, ALS. It discusses the diagnosis and evaluation of ALS and the current understanding of its pathophysiology, including new genetic underpinnings of the disease. This article also covers other motor neuron diseases, reviews how to distinguish them from ALS, and discusses their pathophysiology. RECENT FINDINGS In this ...
متن کاملCell-based therapies for amyotrophic lateral sclerosis/motor neuron disease.
BACKGROUND Amyotrophic lateral sclerosis (ALS), which is also known as motor neuron disease (MND) is a fatal disease associated with rapidly progressive disability, for which no definitive treatment as yet exists. Current treatment regimens largely focus on relieving symptoms to improve the quality of life of those affected. Based on data from preclinical studies, cell-based therapy is a promis...
متن کاملLower motor neuron degeneration in ALS
Running Title: Subgroups of ALS Baumann, F.1,2, Henderson, R.D.12, Ridall, P.G.34, Pettitt, A.N.4, Pamela A. McCombe1,2 1 Department of Neurology, Royal Brisbane & Women's Hospital, Queensland, Australia 2 University of Queensland Centre for Clinical Research, University of Queensland, Australia 3Department of Mathematics and Statistics, University of Lancaster, UK 4Discipline of Mathematical S...
متن کاملThe intriguing case of motor neuron disease: ALS and SMA come closer.
MNDs (motor neuron diseases) form a heterogeneous group of pathologies characterized by the progressive degeneration of motor neurons. More and more genetic factors associated with MND encode proteins that have a function in RNA metabolism, suggesting that disturbed RNA metabolism could be a common underlying problem in several, perhaps all, forms of MND. In the present paper we review recent d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2007
ISSN: 1940-087X
DOI: 10.3791/245